Red Cell Indices As Predictors of Response to Hydroxyurea Therapy in Hbe/Beta Thalassaemia Patients

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Plenary paper Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy

In the phase I/II pediatric hydroxyurea safety trial (HUG-KIDS), school-aged children with sickle cell anemia receiving hydroxyurea at the maximally tolerated dose (MTD) had variable increases in the percentage of fetal hemoglobin (%HbF). To identify predictors of the HbF response to hydroxyurea therapy, baseline clinical and laboratory values (age, sex, hemoglobin concentration, %HbF, reticulo...

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Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy.

In the phase I/II pediatric hydroxyurea safety trial (HUG-KIDS), school-aged children with sickle cell anemia receiving hydroxyurea at the maximally tolerated dose (MTD) had variable increases in the percentage of fetal hemoglobin (%HbF). To identify predictors of the HbF response to hydroxyurea therapy, baseline clinical and laboratory values (age, sex, hemoglobin concentration, %HbF, reticulo...

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Early detection of response to hydroxyurea therapy in patients with sickle cell anemia.

Red blood cells (RBC) and reticulocyte parameters were determined on peripheral blood from a subset of patients enrolled in the multicenter study of hydroxyuea (HU) in sickle cell anemia. Multiple blood samples were obtained every 2 weeks. Cellular indices were measured by flow cytometry. Generalized linear models were used to determine the relationship between the longitudinal trajectories of ...

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Side Effects of Hydroxyurea in Patients with Sickle Cell Anemia

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ژورنال

عنوان ژورنال: Blood

سال: 2016

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v128.22.4838.4838